As much as I love Hotohori, in a 
fight-to-the-death, I think I'd pick Kenshin, 
because, well, Hotohori just wouldn't do it. 
Anyone wanna donate me a Kenshin cel so I can show 
my support de gozaru yo? *LOL*

However on the other hand, in a Vash verses Spike 
battle, I'd put my money on Spike, even though 
Vash is the better gunsman. Why?  Spike has no 
qualms about killing, whereas Vash does. ^_^;  You 
might use a similar idea for Hotohori verses 
Kenshin.  Kenshin would "knock out" Hotohori, but 
Hotohori wouldn't care if he ran Kenshin through. 
Hmmm.